AT2433-A1, AT2433-A2, AT2433-B1, and AT2433-B2 novel antitumor antibiotic compounds produced by actinomadura melliaura. Taxonomy, fermentation, isolation and biological properties

Abstract

Compounds AT2433-A1 (Al), AT2433-A2 (A2), AT2433-B1 (Bl), and AT2433-B2 (B2) were isolated from the cultured broth of Actinomadura melliaura sp. nov. (SCC 1655). Structurally these materials are closely related to rebeccamycin (1), an indolocarbazole antitumor antibiotic. A1, A2, B1, and B2 were active against Staphylococcus aureus A9537, Streptococcus faecalis A20688, Streptococcusfaecium (ATCC 9790), Micrococcus lutea (ATCC 9341), Bacillus subtilis (ATCC 6633). Al and Bl were active against P388 leukemia in mice. © 1989, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.