Is nonangiogenesis a novel pathway for cancer progression? A study using 3-dimensional tumour reconstructions

Abstract

The nonangiogenic lung tumour is characterized by neoplastic cells co-opting the pre-existent vasculature and filling the alveoli space. 3-Dimensional reconstruction of the tumour reveals that this particular tumour progresses without neovascularization and there is no major destruction of the lung's architectural integrity. © 2006 Cancer Research.