Is the onset of psychoactive drug effects compatible with a protein-synthesis mechanism?

Abstract

While many have suggested that protein synthesis may mediate the action of antipsychotic drugs, it is difficult to test. In this math modeling study it is found that the time course of action of the drugs are compatible with a protein-synthesis modeland, furthermore, that the half-lives required by the modelare indeed found in relevant proteins in the brain. © 2003 Nature Publishing Group.