Herpes zoster with skin lesions and meningitis caused by 2 different genotypes of the oka varicella-zoster virus vaccine

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Abstract

A previously healthy boy who had received varicella vaccine developed herpes zoster with meningitis. The vaccine strain recovered from scabs of 3 skin lesions had the wild-type allele at position 108111, a vaccine marker never previously associated with vaccine-associated adverse events. The vaccine strain from cerebrospinal fluid also contained mutations never previously observed at vaccine-associated single nucleotide polymorphisms that would alter amino acid sequences in ORF54 and ORF59. The presence of distinct strains in skin lesions and cerebrospinal fluid indicate that > 1 variant strain may reactivate to cause herpes zoster. © 2008 by the Infectious Diseases Society of America. All rights reserved.

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Levin, M. J., Debiasi, R. L., Bostik, V., & Schmid, D. S. (2008). Herpes zoster with skin lesions and meningitis caused by 2 different genotypes of the oka varicella-zoster virus vaccine. Journal of Infectious Diseases, 198(10), 1444–1447. https://doi.org/10.1086/592452

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