Treatment of pigmentary diseases with needle-shaped maltose containing 5% L-ascorbyl-2-phosphate magnesium

Abstract

Needle-shaped maltose, which is established by nano-technology, is an innovated instrument for new transepidermal drug delivery system (DDS). Chemicals, which are soluble in maltose, can be transferred physically into the epidermis through the stratum corneum by needle shaped maltose. In this study, we used 5% L-ascorbyl-2-phosphate magnesium (APM) maltose for senile freckles of 4 patients and post inflammatory pigmentation of one patient. This instrument was pressed on the pigmentary lesions of the patients once a week for two month and the change of pigmentation was evaluated. The results showed that three cases were "markedly effective" and 2 cases were "moderately effective". Slight erythema and swelling were observed in three cases during the test period, but all symptoms disappeared within three days. In conclusion, our results suggested that APM was effective for hyperpigmentation on the face, and needle-shaped maltose was a useful method of trans-epidermal DDS.