Influence of CMC-Na Concentration to Physical Properties of SNEDDS Kersen leaves Ethanolic Extract Gel

Abstract

Kersen leaves (Muntingia calabura L.) consist of flavonoid, saponin and tannin that has bacteriostatic activity to bacteria caused acnes such as Staphylococcus epidermidis. In this research the extract is loaded into SNEDDS [Self Nano Emulsifying Drugs Delivery System] in order to optimalize the absorbtion of active substances because of the lipophilic character of stratum corneum. SNEDDS then dispersed into hydrogel matrix in order to help aplication on skin. Kersen leaves extracted using ethanol 96 % by maceration method. SNEDDS formula compotition are candlenut oil, tween 80 as surfactant and PEG 400 as co-surfactan in ratio 1:6:1, that contained 30 mg extracts each system. The hydrogel matrix made with carbopol with variation concentrations: 0.06 %; 0.13 % and 0.19 %, then physical property test: organoleptic, homogeneity, pH, viscosity, separation, adhesive and cycling test. Data were analyzed using One Way ANOVA to know the influence of variation of CMC-Na concentration. The results showed that SNEDDS Kersen leaves Ethanolic Extract with 0.06 % carbopol concentration indicated an optimum formula based on physical stability tests. Statistical analysis of the variation of carbopol concentration showed a significant difference on physical characteristics there are: viscosity, pH, homogeneity, and separation test.