Chemical constituents from the stem bark of Zanthoxylum scandens

Abstract

One new dioxoaporphine alkaloid, zanthodione (1), together with nineteen known compounds have been isolated from the stem bark of Zanthoxylum scandens. The structures of these compounds were determined by means of spectral analyses. Except for zanthodione (1), methyl vanillate, vanillic acid, and 2-(4′-hydroxyphenyl)ethyl hexacosanoate, all of the other 16 compounds, as same constituents found in Z. ailanthoides, which were evaluated for inhibition of HIV replication in H9 lymphocyte cells in our previous report in Bioorg. Med. Chem.. The reported decarine, γ-fagarine, and (+)-platydesmine were the most potent anti-HIV constituents, with EC50 values ranging from 0.1 to 1.34 μg/mL and TI (Therapeutic Index) values from 74 to 231, also isolated from the stem bark of this plant.