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Gastroprotective effects of Combretum paniculatum (Combretaceae) leaf extract and fractions on absolute ethanol-induced gastric ulcer in rats

  • Emmanuel P
  • Sandra U
  • Marytheresa O
  • et al.
Future Journal of Pharmaceutical Sciences (2022) 8(1)
DOI: 10.1186/s43094-022-00442-4
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Abstract

Combretum paniculatum (Combretaceae) Vent. is commonly used in traditional medicine to treat ulcers and gastrointestinal disorders, including distended spleens and the liver. This study investigated the gastroprotective effects of C. paniculatum leaf extract and its fractions on absolute ethanol-induced gastric ulcers in rats and explored their effects on endogenous antioxidant (SOD, MDA, GSH, and Catalase) levels. Butanol, n-hexane, and ethyl acetate extracts (100 and 200 mg/kg), omeprazole (20 mg/kg), and control (3% Tween 80) were administered orally.

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APA

Emmanuel, P. I., Sandra, U. C., Marytheresa, O. A., Nwakaego, M. F., Nneoma, O. M., Azubuike, O. C., & Uzor, P. F. (2022). Gastroprotective effects of Combretum paniculatum (Combretaceae) leaf extract and fractions on absolute ethanol-induced gastric ulcer in rats. Future Journal of Pharmaceutical Sciences, 8(1). https://doi.org/10.1186/s43094-022-00442-4

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