In vitro resistance pattern of urinary tract infections-causing bacteria to ampicillin and ciprofloxacin

Abstract

Background: Urinary tract infection (UTI) is caused by microorganism mainly bacteria; therefore, initial empirical therapy of UTI is antibiotic. Once, ampicillin has been used as empirical therapy for UTI; however, it is no longer used as empirical therapy because of its high number of resistance. Theoretically, the resistance is carried by plasmid which will be lost in bacteria population if it has never been used. The objective of this study is to find whether ampicillin has potency to be sensitive again with the same resistance pattern as ciprofloxacin as reference. Methods: Method of this study is cross-sectional study with urine samples collection at primary healthcare centers in Jakarta which were tested its resistance pattern to both of antibiotics. Out of 317 pregnant women who did examination, as many as 27 samples have UTI. Results: Result of this study showed that resistance number of UTI-causing bacteria to ampicillin and ciprofloxacin and are 60.7% and 8.0% respectively and this difference is significant based on chi-square test with a p value of <0.001. Conclusion: Resistance of ampicillin is high so that still cannot be used again as therapy of UTI particularly against Gram-negative bacteria. Surprisingly for Gram-positive bacteria, ampicillin is still likely to be reused as a treatment for UTI, but still need to be investigated further with a larger number of samples.