PENURUNAN KADAR GLUKOSA MENCIT AKIBAT PEMBERIAN KOMBINASI METRFORMIN DAN EKSTRAK BAWANG MERAH

Abstract

Diabetes mellitus (DM) is a metabolic disorder characterized by the high blood glucose level (hyperglycemia). This research aims to know the effect of adding combination of red onion (Allium cepa L.) extract and metformin against male house mice (Mus musculus) on reducing the blood glucose level. This study uses oral glucose tolerance test (OGTT) to determine the body's ability to tolerate the glucose administration by using 18 male house mice (Mus musculus) that divided into 6 groups and each group consisting of 3 mice. Group I as the negative control given 1% of NaCMC suspension; Group II as the Positive Control given metformin suspension of 1.95 mg; Group III as the Positive Control given red onion extract suspension of 7.5 mg; group IV as the Positive Control given red onion extract suspension of 15 mg; group V as the Treatment Control I given a combination of onion extract suspension 7.5 mg + metformin 1,95 mg; and group VI as the Treatment Control II given red onion extract suspension of 15 mg + metformin 1,95 mg. This research result is then analysed using One-Way Anova statistical method. The obtained results show that the dose of the Treatment Control II has significant effect on reducing the blood glucose level. This research needs to be followed up by looking at the effectiveness of the drugs combination.