Flavonoids from Sudanese Albizia zygia (Leguminosae, subfamily Mimosoideae), a plant with antimalarial potency

Abstract

Three flavonoids were isolated for the first time from the Sudanese medicinal plants Albizia zygia. Compounds 1-3 were identified by interpretation of ESI mass data, 1H, 1C and 2D NMR as well as by comparison with published data as 4',7-dihydroxyflavanone (1) 3',4',7-trihydroxyflavone (2), 3-O-methylfisetin (3',4',7-trihydroxy-3-methoxyflavone, 3). All flavonoids were tested against Plasmodium falciparum, and only compound 2 showed high antimalarial activity (IC50 0.078 μg/ml).