Magnesium use on prophylaxis of vasospasm morbidity and mortality rate in subarachnoid hemorrhage

Abstract

A prospective, randomized, nonblind study to examine two points: the clinical incidence of vasospasm morbidity, confirmed by CT; and the mortality of subarachnoid hemorrhage (SAH) patients in 28 days. It shows the comparison of a group of patients that used magnesium (Mg) (intervention, Group 1) with those that did not use Mg (control, Group 2). The main goal of the study was to achieve a Mg serum concentration from 2.5 to 3.5 mg/dl, using a solution of Mg 2% (saline solution 5% 400 ml + MgSO4 10% 100 ml/24 hours), during the first 14 days of aneurysm rupture.