Manufacturing of new formulation of Pyridoxine HCL by direct compression method

Abstract

Vitamins are widely used as a prescription medicine. The aim of the study is to prepare pyridoxine HCl tablets (200 mg) using direct compression technique which is now a days considered a cost effective and simple method of formulation. It can be considered as an appropriate method for hygroscopic and thermolabile substances. In the present study new formulations of Pyridoxine HCl was manufactured by direct compression method using Lactose, magnesium stearate. The present study is divided into two phases. In the first phase new formulation of Pyridoxine HCl was prepared by direct compression method. In the 2nd phase of study new formulation is evaluated for their average weight variation, friability, hardness and other parameters like disintegration. The results showed that all parameters of new formulations are in accordance with the BP/USP limits.