Amides from Huajiao, Pericarps of Zanthoxylum Bungeanummaxim

Abstract

From Huajiao, the pericarps of Zanthoxylum bungeanum maxim. (rutaceae), six unsaturated aliphatic acid amides (1—6) were isolated. Of these, three were identical with the known amides, hydroxy-α-, hydroxy-β and hydroxy-y-sanshools (1, 2 and 3). The other three are new compounds, and the structures were established as (2E, 4E, 8E, 10E, 12E)-2’-hydroxy-N-isobutyl-2, 4, 8, 10, 12-tetradecapentaenamide, and (2E, 4E, 8Z, 11Z)- and (2E, 4E, 8Z, 11E)-2’-hydroxy-N-isobutyl-2, 4, 8, 11-tetradecatetraenamide (4, 5 and 6, respectively). © 1988, The Pharmaceutical Society of Japan. All rights reserved.