Synthesis, spectral studies and biological activity of 3H-1,5- benzodiazepine derivatives

Abstract

Chlorination of 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H- pyrazolo [4,3-d] pyrimidin-7-one (1) with POCl3, afforded 5-(2-ethoxyphenyl)-1-methyl-7-chloro-1H-pyrazolo [4,3-d] pyrimidine (2). Further, compound 2 condensed with different β-diketones/ β-ketoesters 3a-e, to obtain new β-diketones/ β-ketoesters 4a-e. These β-diketones/ β-ketoesters 4a-e were condensed with o-phenylenediamine (o-PDA) to give biologically active 3H-1, 5-benzodiazepines 5a-e. ©ARKAT USA, Inc.