Fabrication and characterization of wound dressings containing gentamicin/silver for wounds in diabetes mellitus patients

Abstract

In this study, the dual functional wound dressings for diabetic patients were fabricated with the help of gentamicin/ cellulose acetate by electrospinning. The resultant nanofibers were functionalized with silver nanoparticles (AgNPs) on its surface by a simple facile wetting process. Herein, gentamicin (Ge) was used for the objective to heal the infection inflammation and Ag NPs were loaded for the antibacterial properties. The resultant CA/Ge/Ag nanofibers were characterized for morphology analysis, chemical interactions examination, release behavior, structure analysis and antibacterial efficiency by scan electron microscope/ transmission electron microscope, FTIR/XPS, ICP study, XRD study and disc diffusion method of antibacterial, respectively. Based on characterization results it was concluded that all samples of CA/Ge/Ag nanofibers showed the antibacterial properties and appreciable release behavior.