A new Vilsmeier-type reaction for one-pot synthesis of pH sensitive fluorescent cyanine dyes

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Abstract

A new Vilsmeier-type reaction is suggested for the synthesis of novel indocarbocyanine pH sensors, which are fluorescent when protonated but nonfluorescent upon proton abstraction. These sensors show significant ratiometric UV-visible as well as fluorescence spectral changes upon subtle variation of pHs with pKa values near neutral. © 2006 Elsevier Ltd. All rights reserved.

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El-Shishtawy, R. M., & Almeida, P. (2006). A new Vilsmeier-type reaction for one-pot synthesis of pH sensitive fluorescent cyanine dyes. Tetrahedron, 62(33), 7793–7798. https://doi.org/10.1016/j.tet.2006.05.063

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