Effects ofmethoxyclopramide combinedwith triple therapy onmicroinflammatory state and immune function in patients with peptic ulcer

Abstract

Objective To investigate the effects of metoclopramide on the micro inflammatory state and immune function in patients with peptic ulcer (PU).Methods From August 2016 to February 2018, used a parallel, controlled and retrospective study, 124 cases of PU patients were selected in our hospital and were divided into the observation group and the control group of 62 patients in each groups accorded to the different treatment methods. The control group were treated with triple therapy, and the observation group were given methoxychloropp on the basis of the control group. The two group of observation times were 14 d.Results The total effective rates of the observation group was 98.4% and significantly higher than in control group (88.7%) (P < 0.05); the Hp clearance rates in the observation group was 90.3% and significantly higher than in the control group (69.4%) (P < 0.05). After treatment, the serum IL-6 and TNF-α of the observation group and the control group were significantly lower than those before treatment (P < 0.05), and the observation group were also lower than that of the control group (P < 0.05). After treatment, the CD4+ of the two groups were increased significantly, and the CD8+ were decreased significantly, the difference compared between the observation group and the control group were also statistically significant (P < 0.05). There were no significant difference compared between the two groups before and after the treatment.Conclusion The metoclopramide in the treatment of PU patients can inhibit the micro inflammatory state, improve the immune function and increase the clearance rate of Hp, thereby improve the therapeutic effect.