Abstract
The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of methylisothiazolinone (MI), which functions as a preservative. The Panel reviewed relevant animal and human data provided in this safety assessment and in a previously published safety assessment of MI and concluded that MI is safe for use in rinse-off cosmetic products at concentrations up to 100 ppm and safe in leave-on cosmetic products when they are formulated to be nonsensitizing, which may be determined based on a quantitative risk assessment.
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Burnett, C. L., Boyer, I., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., … Heldreth, B. (2019). Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics. International Journal of Toxicology, 38(1_suppl), 70S-84S. https://doi.org/10.1177/1091581819838792
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