Granulomatous prostatitis mimicking prostate cancer in a patient with psoriatic arthritis: A case report

Abstract

Granulomatous prostatitis (GP) is an unusual and benign inflammatory condition of the prostate, where autoimmunity has been recognized as a key factor in the pathogenesis of GP in a subset of patients. Clinically, GP poses diagnostic challenges as it may strongly mimic prostate cancer from a clinical, biochemical and radiological point of view. The occurrence of GP in patients suffering from psoriasis, a systemic autoimmune disease, has never been investigated. We describe the case of GP in a patient with psoriatic arthritis presenting with an increased prostate specific antigen level, and evidence of a nodular lesion visualized by prostate multiparametric magnetic resonance imaging, which was highly suspicious for aggressive prostate cancer. Lay abstract Granulomatous prostatitis is an uncommon inflammatory condition of the prostate that can mimic prostate cancer due to increased prostate specific antigen levels and suspect findings from both digital rectal exploration and prostate magnetic resonance imaging. This condition is considered an autoimmune disorder in many cases. We report the association between granulomatous prostatitis and psoriasis, another autoimmune disease.