Toxicity studies on devil's claw herbal medicine

Abstract

Toxicity studies on Devil's claw capsules were conducted using mice by investigating the possible biochemical, hematological and histopathological changes. Acute, subacute and chronic toxicity studies were undertaken by treating mice with a single dose of (81 mg kg-1) body weight for acute (27 mg kg-1) body weight administered orally each other day for 7 days for subacute and an oral dose of (5.4 mg/kg/day) body weight of the drug daily for 90 days for chronic toxicity studies. Devil's claw treated animals did not show any sign of toxicity and none of the animals died during the observation period. Hematological and biochemical studies showed non significant differences among the animals in the treatment groups and control groups. © Medwell Journals, 2010.