Electrophilic: N -trifluoromethylthiophthalimide as a fluorinated reagent in the synthesis of acyl fluorides

Abstract

Herein we report the deoxygenated fluorination of readily available carboxylic acids. A series of acyl fluorides have been synthesized using shelf-stable N-trifluoromethylthiophthalimide as a fluorinated reagent for the first time. Scale-up reactions and sequential cross-couplings were performed successfully to demonstrate the practicability of this fluorination protocol.