MIR200C (microRNA 200c)

Abstract

MicroRNAs (miRNAs) are 20-22 nucleotide long small non-coding RNAs and have a function of regulation of gene postranscriptionally via targeting mainly the 3'UTRs of the genes. miR-200c is a member of miR-200 family with 4 other family members (miR-200a, miR-200b, miR-429 and miR-141) located in chromosome 12 (12q13.31) together with miR-141. miRNAs can be classified as oncomiRs and tumor suppressors according to their target gene and which tissue they are expressed. miR-200c has been shown to be a tumor suppressor in various cancer types. miR-200c has been initially shown to regulate epithelial-mesenchymal transition (EMT) by downregulating ZEB1/2 and upregulating E-cadherin, known epithelial marker. Afterwards, it has been demonstrated that miR-200c also have other important functions in proliferation, cell cycle control, apoptosis, anoikis, invasion, and metastasis of cancer and also in other diseases. Furthermore, miR-200c is a well-established prognostic and diagnostic marker in different cancer types.