Fast-growing subcutaneous tumors with lower-extremity edema and rib lesions: A case of non-hodgkin’s lymphoma in an HIV-1-infected patient

Abstract

Objective: Unusual clinical course Background: Diffuse large B-cell lymphoma (DLBCL) accounts for the large majority of AIDS-related non-Hodgkin’s lymphoma (NHL). DLBCL usually arises in lymph nodes, presenting as a painless rapid swelling mass in the neck, armpit, or groin. Case Report: Here, we report a case of DLBCL that needed only 3 months to develop a tumor 20x15 cm in diameter in the right groin and even caused scrotum swelling and lower-extremity edema. Furthermore, this case of DLBCL had developed other 3 subcutaneous tumors in the chest wall and their diameters were 16x9 cm, 7x7 cm, and 3x3 cm. A thoracic computed tomography (CT) scan presented with bilateral pleural effusion and the chest wall tumors with rib lesions. Conclusions: It is rare that a DLBCL needed only 3 months to develop a tumor 20x15 cm in diameter and even caused scrotum swelling and unilateral lower-extremity edema due to the large mass located in the right groin. Furthermore, it is extremely rare that this lymphoma infiltrated the chest wall and even resulted in rib lesions.