Developments in Pd catalysis: Synthesis of 1H-1,2,3-triazoles from sodium azide and alkenyl bromides

Abstract

Another star for the Palladium: The discovery of reactions promoted by the ubiquitous Pd0 catalysts is still possible. 1H-1,2,3-Triazoles are directly obtained by reaction of alkenyl bromides and sodium azide in the presence of a Pd0-xantphos catalyst (see scheme, xantphos = 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene, dba = trans,trans- dibenzylideneacetone). (Chemical Equation Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.