Pathological laughter following intravenous sodium valproate

Abstract

Background: Pathological laughter can be a sign of epilepsy, psychiatric illness, effect of toxins or psychotropic drugs or of structural brain disease. Method: Case Studies. Result: Two patients developed inappropriate uncontrollable laughter following intravenous sodium valproate for treatment of epilepsy. Conclusion: Pathological laughter can be a side effect of intravenous sodium valproate.