Pharmacokinetics and clinical studies of ceftizoxime in newborn and premature babies

Abstract

Serum concentrations and urinary recovery rates of ceftizoxime (CZX) were investigated in13 mature newborns and 16 premature newborns (with ages 1~17 days) after one shot intravenous injection of10 and 20 mg/kg, respectively, for treatment and prophylaxis of various infections. Obtained data were studied comparatively among the 3 groups, i.e. the 1st group (age:0~3 days), 2nd group (age: 4~7 days) and 3rd group (age: 8 days or older). The clinical investigation was made in 9 male and 6 female newborns aged 3~34 days including 4 pediatrics patients with septicemia (1 with purulent miningitis, 1 with urinary tract infection, 1 with Staphylococcal pneumonia and 1 without complication), 1 with maxillary sinusitis, 5 with bronchopneumonia and 5 with urinary tract infections. © 1988, Japan Antibiotics Research Association. All rights reserved.