Synthesis of p-Chlorocelecoxib from 4-Methylacetophenone & its Spectral Characterization

Abstract

Celecoxib is a non-steroidal anti-inflammatory drug used in the treatment of pain and inflammation. The objective of this study is to synthesize p-chlorocelecoxib by the condensation of 4-methylacetophenone and ethyl trifluoroacetate, followed by reaction with 4-(2-chlorohydrazinly)benzenesulfanimide & identification of celecoxib analogue through several analytical methods like UV visible, IR, TLC, NMR etc. The methods used have been found to be fast, efficient, reproducible and suitable for the identification of celecoxib analogues. The purified β-keto-diester reaction with 4-chlorophenylhydrazine hydrochloric acid gave P-Cl - celecoxib in good yield. © 2011 IGJPS. All rights reserved.