Myrtucomvalones A-C, three unusual triketone-sesquiterpene adducts from the leaves of Myrtus communis 'Variegata'

Abstract

Three new triketone-sesquiterpene adducts, myrtucomvalones A-C (1-3), along with four known compounds (4-7) were isolated from the leaves of Myrtus communis 'Variegata'. Compounds 1 and 2 are the first examples of triketone-cubebane hybrids with an unusual carbon skeleton. Their structures with absolute configurations were determined by spectroscopic data, single crystal X-ray diffraction and electronic circular dichroism (ECD) analyses. Compounds 1-7 displayed inhibitory activities against respiratory syncytial virus (RSV).