Treatment of diffuse sclerosing osteomyelitis of the jaw with denosumab shows remarkable results—A report of two cases

Abstract

Denosumab may play a central role in the treatment of diffuse sclerosing osteomyelitis of the mandible. This report describes two patients who had been treated unsuccessfully with antibiotics and steroids for several years. After denosumab treatment, both patients became pain-free and the radiological examination showed less severe osteomyelitis.