Abstract
Breast cancer remains one of the important global health concerns with high rates of mortality, highlighting the significance of more sophisticated diagnostic methods. Conventional methods, generally comprised of costly imaging and invasive biopsies, are of high burdens. Motivated by the limitations, the present study comes up with an innovative automated solution for the identification of breast cancer using deep learning analysis of mammograms. Moving away from the traditional approaches with inherent pre-processing and feature extraction constraints, this research focuses on a two-pronged improvement strategy: improved mammogram quality and highly optimized deep learning architecture. Specifically, we present a new Optimized InceptionResNetV2 model significantly optimized through the thoughtful addition of large data augmentation to increase robustness, LeakyReLU activation to facilitate gradient flow and accelerate learning, and MeanDropout regularization to mitigate overfitting and improve generalization. The model was also trained using Quantization aware training (QAT) to enable efficient deployment on low-resource devices without significant performance degradation. The performance on our proposed approach for the massive mammogram dataset reflects an evident improvement in detection performance over traditional techniques. Our InceptionResNetV2 optimized achieved state-of-the-art accuracy with outstanding measures of 98.06% sensitivity, 97.05%, positive predictive value (PPV) and specificity of 99.60%, negative predictive value (NPV) of 86.83%, 97.94% accuracy, F1-score of 96.90%, Matthew’s correlation coefficient (MCC) of 90.67%, and AUC of 0.9939. The benefits of proposed system are that it can deliver a more efficient, precise, and possibly cost-effective diagnostic tool for breast cancer. Through synergistic integration of architectural optimization, sophisticated regularization methods, and deployment-aware training, our proposed system enables earlier and more accurate detection. This innovation has the potential to greatly enhance healthcare delivery by equipping radiologists and clinicians with a strong second opinion and initial read capability, ultimately leading to improved patient outcomes and decreased mortality related to this widespread disease.
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Shim, S. O., Hussain, L., Alsolami, E., & Alkinani, M. H. (2025). An Intelligent Smart Dynamic Feature Analysis Based Approach by Utilizing Deep Learning to Improve the Breast Cancer Detection. IEEE Access, 13, 81643–81665. https://doi.org/10.1109/ACCESS.2025.3566353
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