Long-term outcomes after hospitalization with spontaneous bacterial peritonitis

Abstract

Objective: To assess the determinants of long-term outcome in patients with spontaneous bacterial peritonitis (SBP). Methods: This study was conducted retrospectively. Kaplan-Meier (KM) and Cox proportional hazards survival analyses were performed. Results: Altogether, 93 patients with SBP were identified, with their mean age of 57.9±12.9 years, Child-Pugh score 10.4±1.9 and model for end-stage liver disease (MELD) score 20.2±6.8. The etiology of chronic liver disease (CLD) was alcohol-related liver disease (ARLD) (n=58) and viral hepatitis/non-alcoholic steatohepatitis (n=28). SBP was the index presentation of cirrhosis in 26 (28.0%) patients. Overall mortality was 80.6%; among them 81.3% were liver-related, and 33 (35.5%) died during index hospitalization. In total, 70.0% of patients who survived index hospitalization died during follow-up, with a median survival of 12.5 months. Estimated survival at 3 months, 1 year and 5 years was 54.8%, 34.4% and 15.2%, respectively. Non-ARLD etiology for CLD was an independent predictor of overall mortality (HR 3.484, 95% CI 1.802-6.757, P<0.001) and mortality in those surviving hospitalization (HR 2.319, 95% CI 1.210-4.444, P=0.011). Hepatorenal syndrome did not predict outcomes. Two (3.3%) patients surviving hospitalization underwent liver transplantation (LT). Conclusions: One-year survival after hospitalization with SBP remains poor (34.4%) with unacceptably low LT rates. Non-ARLD etiology for CLD is an independent predictor of both overall mortality and mortality after discharge. In view of the projected increase in non-alcoholic steatohepatitis-related CLD, screening strategies for timely CLD diagnosis are warranted.