Transient monosomy 7 in a chronic myelogenous leukemia patient during nilotinib therapy: A case report

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Abstract

Tyrosine kinase inhibitor treated chronic myelogenous leukemia patients with monosomy 7 arising in Philadelphia chromosome negative (Ph-) cells tend to evolve into MDS/AML. However, monosomy 7 in Ph- cells can be a transient finding, and it is not an absolute indication of the emergence of a new myeloid malignancy.

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Jawad, M. D., Go, R. S., Ketterling, R. P., Begna, K. H., Reichard, K. K., & Shi, M. (2016). Transient monosomy 7 in a chronic myelogenous leukemia patient during nilotinib therapy: A case report. Clinical Case Reports, 4(3), 282–286. https://doi.org/10.1002/ccr3.506

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