Preparation and characterization of sustained‐release naringin coating on magnesium surface

Abstract

Given the three‐dimensional multi‐level structure of natural bone and the multi‐factor time‐shifting effect in the healing process after bone trauma, there are plans to introduce drug‐con-trolled release systems into the treatment of orthopedic diseases. To achieve multi‐level loading and controlled release of biologically active substances, it is necessary to create synergistic behavior between biological factors, thereby improving the bone regeneration ability of artificial bone replace-ment materials. A naringin‐loaded (NG) coating was prepared, compared with ultrasonic micro‐arc oxidation (UMAO). The coating was characterized by X‐ray diffraction, infrared spectroscopy, and scanning electron microscopy. The corrosion resistance of the coating was studied through the wetting angle and polarization curve. The high‐performance liquid chromatography method was used to test the release of the drug. It can be seen from the experimental results that the NG coating has a larger wetting angle and better corrosion resistance. In addition, the NG coating produces more apatite substances and has good biological activity. The NG coatings can stimulate the natural bone regeneration and repair process by releasing drugs during the process, which can effectively pro-mote bone regeneration and repair after implantation in the body.