Fabrication and Characterization of Poly(lactic acid)-Based Biopolymer for Surgical Sutures

Abstract

Medical sutures are important surgical aids for promoting wound closure and establishing the ideal environment for wound healing. Several key factors must be considered in medical sutures, including the material of choice for the wound closure, the type of injury (internal or external), the mechanical support required to sustain the closure, the causes of infection, and the suture’s thickness and absorbability. Therefore, this study focuses on producing absorbable surgical sutures from a bio-compatible polymer material called polylactic acid (PLA) along with a PLA–chitosan composite suture initially using the extrusion method followed by the stretching method. The experimental results showed that the PLA suture can be successfully produced and coated with chitosan. The resulting suture elongated up to 148% with an achieved crystallinity of 27%, along with a superior surgical tying and knotting quality. The average thickness of the PLA sutures and PLA sutures coated with chitosan were found to be 0.33 mm and 0.58 mm, respectively. The efficient biocompatibility and wound healing/closure of the sutures were practically deep-rooted using a human skin simulator and rat animal tissue. Based on the degradation study, the manufactured suture in this study proved its degradability in physiological saline water. After a period of 15 days, the sutures lost 50% of their weight and the pH decreased from 6.49 to 4.42.