Spatial representation of overlearned arbitrary visuomotor associations

Abstract

Our movements can be guided directly by spatial information, but also more flexibly through arbitrary rules. We have recently shown that as arbitrary visuomotor mappings became overlearned, they come to rely not only on fronto-striatal circuits, but also on the posterior parietal cortex (PPC). Since this region supports multiple reference frames for hand movements, the question arose whether overlearned visuomotor associations could come to rely on a spatial framework, similar to spatially guided movements. Alternatively, overlearned visuomotor associations could be non-spatial in nature. In this study we investigate the characteristics of the movement representations supporting arbitrary visuomotor mappings by assessing how performance of extensively trained arbitrary visuomotor associations depends on the effector used to provide the response. After extensive training on a set of arbitrary visuomotor associations, subjects were asked to perform the same task in one of two novel settings that varied either the spatial or the motor relationship between visual instructions and finger movements. We found that the change in spatial configuration resulted in a larger amount of interference on the performance of the original mappings than the configuration change in motor coordinates. This result suggests that the visual stimuli became arbitrarily coupled to locations in space and not directly to the finger movements. We infer that overlearned arbitrary visuomotor associations are represented in spatial coordinates, in an effector-independent framework. This result raises the possibility that the previously reported involvement of the posterior parietal cortex in overlearned visuomotor behavior reflects the transition from an arbitrary visuomotor mapping into a spatially based stimulus-location-response mapping.