Effect of tinofedrine (Homburg D8955) on cerebral blood flow in multi-infarct dementia

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Abstract

Tinofedrine, a new derivative of 1-norephedrine, was examined for cerebral vasodilator activity in man. Ten patients with reduced cerebral blood flow (CBF) and multiinfarct dementia were given the drug intravenously. Cerebral blood flow increased significantly by 28% from a mean of 43.3 to 55.5 ml/100 g/min.

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Merory, J., Du Boulay, G. H., Marshall, J., Morris, J., Ross Russell, R. W., Symon, L., & Thomas, D. J. (1978). Effect of tinofedrine (Homburg D8955) on cerebral blood flow in multi-infarct dementia. Journal of Neurology, Neurosurgery and Psychiatry, 41(10), 900–902. https://doi.org/10.1136/jnnp.41.10.900

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