Anti-diabetic role of quercetin and cinnamon on neurobehavioral alterations and biochemical parameters of induced diabetics rats

Abstract

We aim was to evaluate the protective effects of the antioxidants cinnamon and quercetin on neurobehavioral alterations and complications, besides biochemical parameters of induced-diabetics Wistar rats. Diabetes was induced by a single intraperitoneal injection of streptozotocin at a dose of (45 mg/kg). The administration of streptozotocin was considered acting on anxiety behaviors and biochemical parameters in adult Wistar rats. On the other hand, the protective role of antioxidants (cinnamon and quercetin) on streptozotocin-induced disorders was also evaluated. Behavioral tests in the open field (OF) revealed that diabetic animals exhibited an anxious behavior and an alteration in the locomotive and exploratory activities when compared to control. The administration of the cinnamon (2g/kg) and Quercetin (0.5g/kg) by gastric gavage reduces anxiety and decreases hyperglycemia-related harm. However, antioxidants cinnamon and quercetin administration significantly alleviated anxious and depressive behaviors.