Expression of the Novel Hepatitis C Virus Core+1/ARF Protein in the Context of JFH1-Based Replicons

  • Kotta-Loizou I
  • Karakasiliotis I
  • Vassilaki N
  • et al.
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Abstract

Hepatitis C virus contains a second open reading frame within the core gene, designated core+1/ARF. Here we demonstrate for the first time expression of core+1/ARF protein in the context of a bicistronic JFH1-based replicon and report the production of two isoforms, core+1/L (long) and core+1/S (short), with different kinetics.

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Kotta-Loizou, I., Karakasiliotis, I., Vassilaki, N., Sakellariou, P., Bartenschlager, R., & Mavromara, P. (2015). Expression of the Novel Hepatitis C Virus Core+1/ARF Protein in the Context of JFH1-Based Replicons. Journal of Virology, 89(9), 5164–5170. https://doi.org/10.1128/jvi.02351-14

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