Abstract
The effect of foscarnet against human immunodeficiency virus (HIV) was evaluated in nine HIV-infected individuals; six completed 28 days of induction therapy. The overall mean increase in CD4+ lymphocytes was 64 cells per mm3. The mean decline in the HIV antigen concentration was 108 pg/ml (P = 0.03), and suppression was related to systemic foscarnet exposure by a maximum-effect pharmacodynamic model.
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CITATION STYLE
Fletcher, C. V., Collier, A. C., Rhame, F. S., Bennett, D., Para, M. F., Beatty, C. C., … Balfour, H. H. (1994). Foscarnet for suppression of human immunodeficiency virus replication. Antimicrobial Agents and Chemotherapy. American Society for Microbiology. https://doi.org/10.1128/AAC.38.3.604
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