Abstract
We identified a new radical scavenger, 10T024A (C 15H 12N 2O 4), from a culture of the Streptomyces sp. Spectroscopic elucidation indicated that this compound is a new phenazine derivative. 10T024A showed radicalscavenging activity with an ED 50 of 125-M. Moreover, it showed prostaglandin D 2 (PGD 2) and eukotriene B4 (LTB 4) release suppressive activity in rat basophilic leukemia (RBL-2H3) cells, at IC 50: 8μM and 10μM respectively.
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Komoda, T., Tamiya, Y., & Nishikawa, M. (2011). 10T024A, a New phenazine derivative, as a radical scavenger and a prostaglandin, leukotriene release suppressor. Bioscience, Biotechnology and Biochemistry, 75(10), 2056–2058. https://doi.org/10.1271/bbb.110384
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