Combined enzyme and transition-metal catalysis for dynamic kinetic resolutions

Abstract

The preparation of optically pure alcohols, axially chiral allenes, and amine derivatives by using enzymes and transition-metal catalysts through dynamic kinetic resolution (DKR) is reviewed. After a general introduction into enzymatic kinetic resolutions and racemizations catalyzed by transition-metal complexes, selected examples of DKRs are presented, from early work to more recent outstanding contributions, and also applications of this approach. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.