Linking peripheral CD8 + single‐cell transcriptomic characteristics of mood disorders underlying with the pathological mechanism

Abstract

(B) A UMAP map of CD8+ cells from BD, MDD, and Control, and Cells are colored by cell types. Dear Editor, Millions of individuals sustain mood disorders, including bipolar disorder (BD) and major depressive disorder (MDD), contributing a heavy burden to society.1 A previous study suggested dysfunction in the innate immune system underlies the pathophysiology of mood disorders.2 Meanwhile, certain components, such as natural killer (NK) cells and CD8+ lymphocytes, both belonging to killer lymphocytes, are dysfunctions of innate immunity and might participate in the pathogenesis of MDD and BD.3,4 To study the characteristics of CD8+ T cells among BD, MDD, and healthy controls (HCs), 10x single-cell RNA and T cell receptor (TCR) sequencing were applied to analyze the peripheral blood mononuclear cells from participants, including 4 BD patients, 4 MDD patients, and 4 HCs. A total of 14,098, 20,701, and 22,206 CD8+ T cells were isolated from patients with BD, MDD, and HCs, respectively. [Extracted from the article]