Promiscuous Binding of Microprotein Mozart1 to γ-Tubulin Complex Mediates Specific Subcellular Targeting to Control Microtubule Array Formation

Abstract

Huang et al. demonstrate that the microprotein Mzt1 adopts an intercalative binding mode to tightly associate with N-terminal domains of multiple γ-TuRC subunits. Furthermore, they show that promiscuous binding of Mzt1 in γ-TuRC regulates γ-TuRC assembly and targeting, controlling subcellular localizations of γ-TuRC and modulating microtubule formation in fission yeast.