Clinical and pharmacological data in covid-19 hospitalized nonagenarian patients

Abstract

Introduction. Despite the impact of SARS-CoV-2 infection in geriatrics, data on nonagenarian patients is scarce. The aim of this study is to describe the clinical features of COVID-19-diagnosed nonagenarians, as well as its clinical evolution and therapeutic response. Material and methods. Retrospective observational study of nonagenarians, admitted for COVID-19. Sociodemogra-phic and clinical variables were registered, including previous polypharmacy. Blood analysis data and COVID-19-specific treatment were registered. Results. A total of 79 patients were included, with 50.6% (40 patients) of mortality. None of the comorbidities registered correlated with mortality, which was significantly higher among patients with moderate/complete functional depen-dence, compared to those mild-dependents/independents (59.5% vs 40.5%; p=0.015). Most prescribed drugs were hy-droxychloroquine/chloroquine and azithromycin. Non-survi-vors presented higher counts of leukocytes and neutrophils, and higher lymphopenia. Conclusions. Nonagenarians with functional dependen-ce presented higher mortality, irrespective of comorbidities or treatment received. Implementing an integral geriatric evalua-tion would enhance the implementation of personalized therapeutic strategies for nonagenarians.