Effect of topical ethanol extracts of Morinda citrofilia L. leaves on excisional wound healing

Abstract

This study was proposed to find the beneficence of noni (Morinda citrifolia L.) leaves ethanol extract as a treatment for wound healing in rat skin. This experimental study was done by making excisional wound on the back of Wistar rats then divided them into four groups which were given topical treatments of noni extract; control group treated by base gel and three treatment groups were given 10% (w/w) povidone iodine, 10% ethanol extract gel of noni leaves and 20% (w/w) ethanol extract gel of noni leaves, recpectively. The result of this study showed that 10% topical morinda ethanol extract gel (10 mg mL-1) had a significant effect on rat skin excisional wound healing compared to 10% povidone iodine (p<0.05). The level of plasma MDA of rats in every group was also examined, however there was no significant difference between treatment and control groups. This research showed that noni extract could improved excisional woung healing. © 2013 Asian Network for Scientific Information.