Determination of hemoglobin A(1C) in normal and diabetic mice: Neonatal streptozotocin-induced diabetic mice and KK-Ay mice

Abstract

We have determined Hemoglobin A(1C) (HbA(1C)) in normal, neonatal streptozotocin-induced diabetic animals (NSZ), a model of lean-type non- insulin-dependent diabetes mellitus (NIDDM) with hypoinsulinaemia, and KK-Ay mice, a model of obese-type NIDDM with hyperinsulinaemia. The HbA(1C) of NSZ mice was slightly increased from 5 to 20 weeks while the HbA(1C) of KK-Ay mice was markedly increased from 5 to 10 weeks. Our findings showed a difference between experimentally-induced (NSZ) and genetically (KK-Ay) diabetic animals.