Fast-local and slow-global neural ensembles in the mouse brain

Abstract

Ensembles of neurons are thought to be coactive when participating in brain computations. However, it is unclear what principles determine whether an ensemble remains localised within a single brain region, or spans multiple brain regions. To address this, we analysed electrophysiological neural population data from hundreds of neurons recorded simultaneously across nine brain regions in awake mice. At fast subsecond timescales, spike count correlations between pairs of neurons in the same brain region were stronger than for pairs of neurons spread across different brain regions. In contrast at slower timescales, withinand between-region spike count correlations were similar. Correlations between high-firingrate neuron pairs showed a stronger dependence on timescale than low-firing-rate neuron pairs. We applied an ensemble detection algorithm to the neural correlation data and found that at fast timescales each ensemble was mostly contained within a single brain region, whereas at slower timescales ensembles spanned multiple brain regions. These results suggest that the mouse brain may perform fast-local and slow-global computations in parallel.