Journal ArticleOPEN ACCESS

Microbial transformations of natural antitumor agents: conversion of lapachol to dehydro-α-lapachone by Curvularia lunata

Applied and Environmental Microbiology (1979) 38(2) 311-313
DOI: 10.1128/aem.38.2.311-313.1979
19Citations
Citations of this article
15Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Microbial transformation of lapachol, a naturally occurring naphthoquinone, was carried out by Curvularia lunata (NRRL 2178). The fungus brings about oxidative cyclization of the substrate to dehydro-α-lapachone, which was isolated and characterized by nuclear magnetic resonance and mass spectral analyses; its structure was verified by chemical synthesis. The metabolite is naturally occurring chromene possessing antibacterial and antitumor activities.

Cite

CITATION STYLE

APA

Otten, S., & Rosazza, J. P. (1979). Microbial transformations of natural antitumor agents: conversion of lapachol to dehydro-α-lapachone by Curvularia lunata. Applied and Environmental Microbiology, 38(2), 311–313. https://doi.org/10.1128/aem.38.2.311-313.1979

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free