Effects of gamma‐hydroxybutyrate on chick behaviour, electrocortical activity and crossed extensor reflexes

Abstract

Convulsant and anticonvulsant effects of gamma‐hydroxybutyrate (GHB) have been studied in chicks. When administered alone, GHB produced weak myoclonic seizures accompanied by electrocortical synchrony and spikes. GHB was found to protect chicks against leptazol‐ and picrotoxin‐induced seizures. A slight potentiation of strychnine‐induced seizures was evident. 1972 British Pharmacological Society